The under-eye area is one of the first places where signs of aging, fatigue, and dehydration begin to appear — from fine lines and puffiness to dark circles and thinning skin. While traditional fillers and creams can offer some improvement, a more advanced, regenerative solution is making waves in the aesthetics world: polynucleotides.
These powerful skin-healing molecules are now the go-to treatment for rejuvenating delicate under-eye skin. But with so many products on the market — Plinest Eye, Rejuran i, Vitaran I, and Nucleofill Soft/Medium — which one is right for you?
Let’s break down the top four and help you find the perfect fit for your skin.
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What Are Polynucleotides?
Polynucleotides (PN) are highly purified DNA fragments derived from salmon or trout. When injected into the skin, they:
• Stimulate fibroblasts (your skin’s repair cells)
• Promote collagen and elastin production
• Deeply hydrate the tissue
• Reduce inflammation and pigmentation
For the under-eye area, they provide a natural, non-volumizing alternative to fillers, offering smoother, brighter, and healthier skin over time.
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Top 4 Polynucleotide Products for Under-Eyes
Nucleofill Soft or Medium
• Concentration: 15–20 mg/mL (1.5–2.0%)
• Best for: Mature skin, deeper wrinkles, tissue lifting
• Why We Love It: The most concentrated of the four, Nucleofill provides strong biostimulation, lifting effect, and antioxidant support. Ideal for more advanced signs of aging or deeper tear troughs. A favorite for those looking for more dramatic improvement.
Plinest Eye
• Concentration: 7.5 mg/mL
• Best for: First signs of aging, sensitive skin
• Why We Love It: Specifically designed for the eye area, Plinest Eye delivers gentle yet effective hydration and tissue repair. It’s ideal for those new to polynucleotides or with delicate skin that’s prone to puffiness.
Rejuran i
• Concentration: 10 mg/mL
• Best for: Fine lines, pigmentation, and crepey texture
• Why We Love It: Rejuran is one of the original polynucleotide-based skin boosters from Korea. The “i” version is tailored for the eyes, improving skin quality, tone, and firmness with minimal risk of swelling.
Vitaran I
• Concentration: 10 mg/mL
• Best for: Maintenance, hydration, and early aging
• Why We Love It: Vitaran is known for its purity and versatility. Vitaran I is suitable for preventative care and light rejuvenation, offering a fresh, hydrated appearance with a very natural feel.
